Insulin hypoglycemia and hypothalamic hyperphagia
نویسندگان
چکیده
منابع مشابه
Food Intake and Hypothalamic Hyperphagia †
Animals eat different amounts of different diets, which implies that they recognize some quality or qualities of the diet. Both Cowgill' and Adolph1 were aware of this problem, but no one appears to have made a systematic attempt to define the dietary quality recognized by animals. Both of these workers were led to the opinion that their animals seemed to "eat for calories," i.e., for energy. H...
متن کاملExperimental Hypothalamic Hyperphagia in the Albino Rat *
Experimental study of hypothalamic obesity is based upon a foundation laid by clinicians who described lesions of the hypophysiohypothalamic region in obese human patients. Because of the non-specific character of the lesions which they found, previous investigation was naturally directed toward discovering whether damage to the hypothalamus, to the hypophysis, or to both was necessary to produ...
متن کاملBrain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
OBJECTIVE An impaired ability to sense and appropriately respond to insulin-induced hypoglycemia is a common and serious complication faced by insulin-treated diabetic patients. This study tests the hypothesis that insulin acts directly in the brain to regulate critical glucose-sensing neurons in the hypothalamus to mediate the counterregulatory response to hypoglycemia. RESEARCH DESIGN AND M...
متن کاملLong-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy.
A major side effect of insulin treatment of diabetes is weight gain, which limits patient compliance and may pose additional health risks. Although the mechanisms responsible for this weight gain are poorly understood, it has been suggested that there may be a link to the incidence of recurrent episodes of hypoglycemia. Here we present a rodent model of marked weight gain associated with weekly...
متن کاملVentromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
OBJECTIVE The counterregulatory response to insulin-induced hypoglycemia is mediated by the ventromedial hypothalamus (VMH), which contains specialized glucosensing neurons, many of which use glucokinase (GK) as the rate-limiting step in glucose's regulation of neuronal activity. Since conditions associated with increased VMH GK expression are associated with a blunted counterregulatory respons...
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ژورنال
عنوان ژورنال: Psychonomic Science
سال: 1970
ISSN: 0033-3131
DOI: 10.3758/bf03329084